Applied Microbiology and Beneficial Microbes

Myocardial infarction and gut micro biota: An incidental connection

The main therapeutic goal of modern cardiology is to develop novel approaches to minimize inflammation, myocardial necrosis/apoptosis, and enhance cardiac repair after MI. Though MI can be affected by genetic and environmental factors, the search for targeting lifestyle factors has been of greater interest. One such potential factor is the micro biota, the human intestinal microbial community. The disruption of intestinal flora structure provokes MI and poor prognosis. Since gut micro biota is readily modifiable through a variety of interventions, it can be targeted to modulate the host signalling pathways involved in inflammation and MI pathogenesis. Symbiosis bacteria can reduce ischemia/reperfusion injury and inflammation; moreover, they can regulate lipid metabolism, blood pressure, apoptosis, MI size, and overall cardiac survival. In this review, we provide an overview of the development of MI following the symbiosis micro biota and give an update on a micro biota-based therapeutic strategy to delay or prevent MI.