Applied Microbiology and Beneficial Microbes

Conventional methods for cancer treatment including radiotherapy, chemotherapy, and immunotherapy have limitations. In this regard, a new practical strategy, combination of conventional methods with bacteriotherapy, showed a considerable effect on tumor regression and metastasis inhibition. Bacterial-assisted tumor-targeted therapy as therapeutic/gene/drug delivery vehicles is a huge interest for research in the treatment of tumors. The use of whole live, attenuated and/or genetically-modified bacteria only or with combination of conventional methods with different strategies was found to be superior in the experimental models of cancer (tumor regression and increased survival rate).