Mohammad Magdy El-Metwally
Damanhour University, Egypt
Title: New Bioactive Secondary Metabolites from Streptomyces lividans AM
Biography
Biography: Mohammad Magdy El-Metwally
Abstract
During our search for bioactive compounds from actinomycetes, the Streptomyces lividans AM was large scale fermented on rice solid medium, followed by working and purification, affording the new 1-nona-decanoyl, 4-oleyl disuccinate (1), the bacterial new metabolite: filoboletic acid; (9Z,11E)-8,13-dihydroxy octadeca-9,11-dienoic acid (2), and the microbial new metabolite: sitosteryl-3b-D-glucoside (3). This was in addition to further ten known bioactive metabolites: ferulic acid (4), glycerol linoleate, linoleic acid, indol-3-acetic acid methyl ester, 4-hydroxy-phenyl acetic acid, 2-hydroxy-phenyl acetic acid, 3-(hydroxy-acetyl)-indole, indol-3-carboxylic, p-hydroxy-benzoic acid and uracil. The chemical structures of the new metabolites (1-3) were confirmed by extensive 1D and 2D NMR and mass spectrometry, and by comparison with literature data. The antimicrobial activity of the strain extract was studied using a set of microorganisms. The isolation and taxonomical characterization of Streptomyces griseorubens strain ASMR4 is reported as well.