Mohammad Magdy El Metwally
Damanhour University, Egypt
Title: New bioactive secondary metabolites from Streptomyces lividans
Biography
Biography: Mohammad Magdy El Metwally
Abstract
During our search for bioactive compounds from actinomycetes, the Streptomyces lividans was large scale fermented on rice solid medium, followed by working and purification, affording the new 1-nona-decanoyl, 4-oleyl disuccinate (1), the bacterial new metabolite: filoboletic acid; (9Z,11E)-8,13-dihydroxy octadeca-9,11-dienoic acid (2), and the microbial new metabolite: sitosteryl-3 -D-glucoside (3). This was in addition to further ten known bioactive metabolites: ferulic acid (4), glycerol linoleate, linoleic acid, indol-3-acetic acid methyl ester, 4-hydroxy-phenyl acetic acid, 2-hydroxy-phenyl acetic acid, 3-(hydroxy-acetyl)-indole, indol-3-carboxylic, p-hydroxy-benzoic acid and uracil. The chemical structures of the new metabolites (1-3) were confirmed by extensive 1D and 2D NMR and mass spectrometry, and by comparison with literature data. The antimicrobial activity of the strain extract was studied using a set of microorganisms. The isolation and taxonomical characterization of Streptomyces griseorubens strain ASMR4 is reported as well.